The term multi-organ transplantation embraces both combined transplantation and multiple transplantation. Combined transplantation is defined as the simultaneous transplantation of two organs into the same person; examples include pancreas-kidney transplantation (performed for the first time in Minneapolis, USA in 1966), heart-lungs transplantation (performed for the first time in Houston, USA in 1968), and liver-intestine transplantation (performed for the first time in Toronto, Canada in 1989). Multiple transplantation refers to the transplantation of three or more organs. The en-bloc transplantation of three or more abdominal organs is called multivisceral transplantation.