The Convention has since been revised. The change affects the procedure for amending the technical appendices (Guidelines etc.):

In future the appendices may be amended more easily in order to reflect scientific and technological advances as well as the latest research findings in the relevant fields (Protocol of amendment to the European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes dated 22 June 1998).

The European Community has now adopted the Protocol of amendment (Directive 2003/584/EC).

Germany signed the Protocol of amendment on 26 November 1999; it entered into force in Germany on 2 December 2005.