Further information on on-target effects can be found here, for example:

Albrecht, S., König, H., & Sauter, A. (2021). Genome Editing am Menschen. Endbericht zum Monitoring. In TAB-Arbeitsbericht Nr. 191, 8. Büro für Technikfolgen-Abschätzung beim Deutschen Bundestag (TAB). https://doi.org/10.5445/IR/1000141083

Weisheit, I., Kroeger, J. A., Malik, R., Klimmt, J., Crusius, D., Dannert, A., Dichgans, M., & Paquet, D. (2020). Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing. In Cell Reports 31 (8), 107689. https://doi.org/10.1016/j.celrep.2020.107689

Wienert, B., & Cromer, M. K. (2022). CRISPR nuclease off-target activity and mitigation strategies. In Front Genome Ed 4, 1050507. https://doi.org/10.3389/fgeed.2022.1050507

Boutin, J., Cappellen, D., Rosier, J., Amintas, S., Dabernat, S., Bedel, A., & Moreau-Gaudry, F. (2022). ON-Target Adverse Events of CRISPR-Cas9 Nuclease: More Chaotic than Expected. In CRISPR J 5 (1), 19-30. https://doi.org/10.1089/crispr.2021.0120